These are not in any order.
Speak: Melinda Sordino walks into Biology class, only seat available is next to Dave Petrakis.
Twilight: Bella Swan walks into Biology class, only seat available is next to Edward Cullen.
Speak: Melinda passes out when she's about to dissect a frog. Dave attempts to wake her up, and claims his dad is a doctor.
Twilight: Bella nearly passes out during the blood-typing. Edwards dad is a doctor.
Speak: Melinda is attacked by Andy Evans at the end of the movie, she picks up some chemical and throws it in his eyes.
Twilight: Bella is attacked by James, and sprays pepper spray into his eyes.
Speak: While Melinda does not talk through most of the movie, there is internal monologues.
Twilight: Bella has internal monologues at certain points in the film.
That's all I can think of for now, if you can think of any leave it in a comment!
**I must point out that I am in no way saying Speak is like Twilight. Twilight is about fictional characters, while Speak is about a very serious subject. I just wanted to point out the ironic similarities.**